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5–four μmol/L range,[156][157] the concentration of serotonin in synaptic vesicles was measured at 270 mM.[182] pursuing vesicular launch, the resulting focus of serotonin inside the synaptic cleft, to which serotonin receptors are uncovered, is approximated to generally be about 300 μmol/L. So, although in vitro receptor binding affinities,
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